Introduction
Lion’s Mane and Reishi are two of the most respected medicinal mushrooms in the nootropics and wellness world. Both are praised for their ability to support the brain, reduce inflammation, and enhance mental clarity. However, many users report something unexpected: a wave of anxiety after taking this popular stack.
If you’re feeling jittery, overstimulated, or restless after combining Lion’s Mane and Reishi, you’re not alone. In this article, we’ll explain why this stack can trigger anxiety, what symptoms to look out for, and how to fix it without giving up the benefits.
Why People Stack Lion’s Mane and Reishi
This mushroom duo is growing in popularity because it combines two powerful but complementary effects:
- Lion’s Mane boosts nerve growth factor (NGF), which promotes brain regeneration and clarity
- Reishi is known as the “Mushroom of Immortality” for its immune-boosting, calming, and adaptogenic properties
Together, they create a stack that seems perfect for ADHD, anxiety, brain fog, and stress.
“My anxiety is greatly reduced since starting Lion’s Mane and Reishi… but I can’t sleep.” – r/Nootropics user
However, not everyone has a smooth experience.
Why This Stack Can Cause Anxiety
Despite being natural, these mushrooms are bioactive powerhouses. Here are the most common reasons they may trigger anxiety:
1. Overactivation of NGF
Lion’s Mane stimulates NGF, which helps your brain build and repair neurons. But for some people (especially those with ADHD or sensitive nervous systems), this can feel like mental overstimulation.
“Lion’s Mane gave me crazy dreams and a racing heart… had to stop.” – r/MushroomSupplements
2. Kappa-opioid effects of Reishi
Reishi may act on kappa-opioid receptors, which can trigger low mood or anxiety in some users, especially at high doses or when combined with other strong compounds.
3. Histamine Response or Allergy
Both mushrooms, especially if not pure fruiting body extracts, can cause a histamine or allergic response — leading to brain fog, anxiety, or gut issues.
4. Timing or Dosage Mistakes
Taking both mushrooms at the wrong time of day or in high doses can overload the system. Reishi in the morning can make you drowsy; Lion’s Mane at night can keep you awake.
Common Symptoms Users Experience
Reddit and Quora users frequently mention:
- Racing thoughts
- Insomnia
- Chest tightness or fast heartbeat
- Inner restlessness
- Short temper or emotional spikes
Some users report this after just 1 capsule, especially if they’re new to nootropics or have ADHD/anxiety backgrounds.
3 Ways to Adjust Your Stack for Calm
1. Lower the Dose
Start with 250mg of Lion’s Mane and 500mg of Reishi, once daily. Gradually build up if no side effects.
Avoid multi-mushroom blends with unclear dosages.
2. Switch to Fruiting Body Only
Avoid mycelium-based or grain-grown mushrooms, which can introduce allergens or irritants.
Look for brands that use 100% fruiting body and are dual-extracted.
3. Time It Right
- Lion’s Mane: Morning with food
- Reishi: 1–2 hours before bed
This gives you clarity during the day and relaxation at night without overlap that could trigger anxiety.
Bonus: Stack with Calming Agents
If anxiety persists, consider adding:
- L-Theanine (200mg) – smooths stimulation
- Magnesium Glycinate (200mg) – reduces stress
- Ashwagandha (300–600mg) – adaptogen that balances mood
When to Stop or Talk to a Doctor
If you experience:
- Ongoing insomnia or panic attacks
- Palpitations or breathing issues
- Any allergic reactions (itching, swelling)
You should stop immediately and consult a doctor. Mushroom supplements are powerful tools but not for everyone.
Also check for medication interactions – especially antidepressants or ADHD meds.
Real-World User Quotes
“I took one capsule and had noticeably elevated anxiety and lowered mood. Felt like a crash.” – r/MushroomSupplements
“I love the combo, but I had to reduce the dose and take Reishi at night to stop the jittery feeling.” – r/Nootropics
User feedback is gold. It shows there’s no one-size-fits-all, but you can learn and adapt.
Final Take: Is This Stack Right for You?
The Lion’s Mane + Reishi stack can be amazing for mental clarity, immune support, and emotional balance. But for some, it might bring unwanted anxiety if not dosed or timed correctly.
Start slow. Track your response. Adjust your stack.
And if you’ve tried all the above and still feel off? Lion’s Mane or Reishi might not be the right fit for your body — and that’s okay.